OncoGuideeducation

THE CURRICULUM

Getting started

Learn the biology and evidence How direct-to-tumor cancer treatments work

Cell-therapy lesson library

Cell-therapy lesson library Building an engineered T cell Cell therapies as living drugs Compare immune-cell recognition systems Cytokines and programmable receptors Gamma-delta decision framework Gamma-delta T-cell foundations How to engineer T cells inside the body Reading cell-therapy evidence The journey through a solid tumor

Education concepts

Education concepts Antigen-processing machinery B2M (beta-2 microglobulin)CAR (chimeric antigen receptor) anatomy Central dogma: from DNA to RNA to protein Clinical actionability Cross-presentation ctDNA (circulating tumor DNA) units and detection limits Hazard ratio HLA (human leukocyte antigen)Immune escape Innate vs adaptive immunity Kaplan–Meier curves Lead-time bias LNP (lipid nanoparticle)mRNA construct anatomy Neoantigen Pathologic complete response (pCR)Positive predictive value and base rates Prognostic versus predictive biomarkers Residual cancer burden (RCB)Surgical margins Survival endpoints T-cell priming and the three-signal model T-cell states TCR (T-cell receptor)The immune-cell roster TNM staging

Education illustration register

Education illustration register

How a personalized cancer vaccine is designed

How a personalized cancer vaccine is designed How engineered immune cells can attack a solid tumor Read pathology and surgery results Read trial claims and survival statistics Understand how standard treatment works Understand how the immune system recognizes cancer Choose a target with a usable safety window Dose a vaccine and measure its response Read the safety plan for engineered cells Read tumor and normal data before choosing targets Turn selected targets into an mRNA message

Modeling tumor response

Modeling tumor response Verification and feedback loops

Molecular profiling — one tumor, many lenses

Molecular profiling — one tumor, many lenses PARP, recycling, and cell survival Autophagy and proteostasis — two cleanup systems Autophagy: traffic, flow, and dependence ctDNA and residual disease over time ctDNA PPM and MRI reads CUL3, NRF2, ferroptosis, and BET — defenses and transcription DNA — the blueprint From a molecular finding to a treatment question Lipid metabolism and mTOR — two nutrient systems, two direction traps Notch, Wnt, and FGFR4 — messages are not dependencies Oxidative metabolism and stress — engine, sparks, and shields PARP trapping and recycling PI3K, AKT, and mTOR: competing effects on repair and recycling Protein — expression and activation RAG1 S382* pathway hypothesis — what is observed, inferred, and testable Reading a functional experiment RNA — the activity layer Spatial biology: where are the cells?T-cell receptors and TCR sequencing The EVEE pathway hypotheses — course index Understand HRD and PARP biology What a living tumor model can tell us

Multi-omics foundations

Multi-omics foundations Cell identity, state, and subtype Comparisons and the evidence ladder Copies, alleles, and clones Epithelial cells and breast tissue Immune presence and tumor recognition Reading RNA counts Splicing and DNA repair

Oncology 101 — the minimum vocabulary

Oncology 101 — the minimum vocabulary Dendritic cells and T-cell priming How tumors escape a treatment Ligands and receptors T-cell states: presence and function

Reading a tumor report

Reading a tumor report Immune-hot, excluded, or cold Measuring T-cell engagement Understand omics and multi-omics

Targeted therapy modalities

Targeted therapy modalities Compare targeted therapy formats How targeted therapies act Overlap and sequencing Questions for a targeted-therapy proposal Timing: development, readiness and dosing Tissue and sample requirements

Understand local treatment and immune priming

Understand local treatment and immune priming Compare ablation, radiation and radioligands How local injury can create immune signals Read a local-treatment proposal Read evidence for local and systemic combinations What imaging and tissue can tell us after local treatment Why disease setting changes the timing question

Why a personalized cancer vaccine can help

Why a personalized cancer vaccine can help HLA and antigen presentation in vaccine design How a personalized vaccine is manufactured Immunopeptidomics: measuring peptide display Moved: Leukopak banking Moved: TCR and TCR sequencing Porton mRNA manufacturing handoff Read a neoantigen design board

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Education/Moved: TCR and TCR sequencing

THE EDUCATION LIBRARY

Moved: TCR and TCR sequencing

This concept page now lives at tcr-and-tcr-sequencing.

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